Pharmaceutical suspensions /

Abstract

Pharmaceutical Suspensions focuses on the formulation, preparation, and evaluation of suspension dosage forms, which are heterogeneous systems consisting of finely divided insoluble solid particles dispersed in a liquid medium. The text explains the physicochemical principles governing suspensions, including particle size, surface properties, and interparticle forces, which influence the stability and performance of the formulation. It emphasizes the importance of controlling sedimentation, flocculation, and aggregation to ensure uniform dosing and patient acceptability. Key formulation strategies are discussed, including the use of: Wetting agents to enhance the dispersion of particles Suspending agents to increase viscosity and reduce sedimentation Flocculating agents to prevent caking and improve redispersibility

The book also covers methods of preparation, such as dispersion and precipitation techniques, along with evaluation parameters like sedimentation volume, viscosity, particle size distribution, and stability testing. Applications in oral, topical, and parenteral suspensions are highlighted, with attention to bioavailability, patient compliance, and product quality.